During which phase do spindle fibers attach to centromeres of the chromosomes?

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During metaphase, spindle fibers attach to the centromeres of the chromosomes. This is a critical step in the process of cell division because it ensures that the chromosomes are properly aligned along the metaphase plate and that they are positioned to be accurately separated into daughter cells. The attachment of the spindle fibers, which are part of the mitotic spindle, helps to pull the sister chromatids apart in the subsequent phase of anaphase. Metaphase is characterized by this alignment and stabilization, allowing for an error-free distribution of genetic material.

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